Endocrine Abstracts

In the late years ISGLT2 have became an usual choice to treat diabetes. The inhibition of the sodium-glucose co transporters (SLGT2) inhibits also the glucose reabsorption in the proximale tubule and increases the glucose excreted in the urine. Therefore hyperglycemia decreases and so does weight. This is a very convenient side effect since type 2 DM is highly associated with overweight/obesity. We show the results of HbA1c and weight evolution after starting canaglifozina 100...

Changes in HbA1c and weight after 1 year on dapaglifozina added to the previous treatment.SGLT2 inhibitors are becoming a common and useful drug to treat type 2 diabetes.The inhibition of the sodium-glucose co transporters (SLGT2) inhibits also the glucose reabsorption in the proximale tubule and increases the glucose excreted in the urine.Therefore hyperglycemia decreases and so does weight as happens with t...

Introduction: From November 2013 it is available in Spain a new drug to treat type 2 diabetes (DM2): dapagliflozina. The new mechanism of action consists in the inhibition of the sodium–glucose co transporters (SLGT2) inhibiting glucose reabsorption in the proximale tubule and increasing glucose excreted in the urine. Therefore hyperglycaemia decreases and so does weight as a consequence of glycosuria. This is a very convenient side effect since DM2 is highly associated w...

Introduction: Intrathyroidal parathyroid adenomas (IPA) are a rare cause of primary hyperparathyroidism (PHP) and their differential diagnosis includes other parathyroid and thyroid lesions. Although <7% of parathyroid adenomas are intrathyroidal, this location represents almost 20% of ectopic cases and their preoperative identification can pose difficulties, often being an intraoperative finding.Clinical case: A 70-year-old woman diagnosed with brea...

Introduction: Depression, anxiety and eating disorders appear more frequently in patients with type 2 diabetes and are associated with worse metabolic control and higher risk of developing micro and macrovascular complications. The aim of this study was to determine the prevalence of psychiatric comorbidities in diabetic patients, candidates for therapy with SGLT2 inhibitors (SGLT2i) and to evaluate their clinical profile and degree of metabolic control before beginning the tr...

Introduction: Cyclic Cushing’s Syndrome (CCS) is a rare disorder in which rhythmic fluctuations in the secretion of ACTH trigger cyclic variations in the production of adrenal steroids and an extremely variable clinical presentation. It should be considered when clinical hypercortisolism coexists with normal cortisol levels and a paradoxical response to the dexamethasone test, and when selective transsphenoidal adenomectomy fails after an uncomplicated intervention.<p...

Introduction: McCune Albright syndrome (MAS) is a rare, sporadic disease that affects the skin, skeleton and several endocrine systems, caused by an activating mutation in the GNAS gene that leads to endocrine cell hyperfunction and increased cell proliferation. The development of thyroid carcinoma in MAS is considered an uncommon event and, on the other hand, it is well established that acromegaly is associated with an increased prevalence of malignant tumors including thyroi...